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Glutathione and Vitamin D: A Powerful Essential Connection

Wellness Resources

Some things need to be shouted from the rooftop or have blazing headlines to get people’s attention. In this case, I am referring to the recently discovered special connection between vitamin D and glutathione. On their own, these two powerful nutrients affect incredible numbers of cellular actions and functions and vast numbers of gene signals. The story goes deeper. Vitamin D needs adequate glutathione to work. If you are going to thrive in these challenging times, you must have sufficient glutathione to activate vitamin D.

Vitamin D

Individuals often take vitamin D3 supplements if they are not able to obtain adequate vitamin D from exposure to sunshine. With supplementation, blood test levels may improve for some individuals. Yet, for others, levels barely improve. This may be due to insufficient intake, poor absorption, and/or vitamin D receptor gene SNPs.

Recent findings show that poor response to vitamin D supplementation goes even further. If you do not have adequate stores of the antioxidant glutathione, vitamin D activation does not occur. Vitamin D activation occurs primarily in the liver, which depends upon your antioxidant stores of glutathione. If your glutathione status is low, Vitamin D remains inactivated and your blood levels will remain low.


Glutathione is a natural, powerful antioxidant system in your body. The liver and immune system as well as the rest of your organs and tissues deeply depend upon it for their proper function. The liver is its primary site of manufacturing. Glutathione can be produced by three amino acids, cysteine, glutamine, and glycine, and is supported by other antioxidants like vitamin C, curcumin, magnesium, selenium, zinc, B vitamins, lipoic acid, and N-acetyl Cysteine.

Glutathione and Vitamin D Connection

Recent nutritional science findings have discovered this exciting connection with glutathione and vitamin D. A 2014 cross-sectional study evaluated vitamin D and glutathione status in 693 adults. Lab results showed that vitamin D status was positively and independently associated with blood levels of glutathione. Individuals who had adequate glutathione also had good vitamin D levels. Subsequent research has discovered some of the mechanisms.

A 2018 study with obese adolescents reported on a link between vitamin D deficiency and low glutathione levels. Researchers discovered mechanisms that demonstrated glutathione status positively influences the bioavailability of vitamin D. Adequate glutathione status in the liver upregulates vitamin D regulatory genes, which activates vitamin D. However, insufficient glutathione status impaired the vitamin D regulatory genes in the liver.

The conclusion of the study stated “Thus, the vitamin D supplements widely consumed by the public are unlikely to be successful unless the GSH (glutathione) status is also corrected.”

Other 2019 findings confirmed that high fat diets induced fatty liver, which reduced glutathione levels in the liver. Fatty liver congestion caused increased free radicals and oxidative stress, which led to depleted glutathione. This in-turn compromised vitamin D regulatory genes. The liver is the chief site for vitamin D synthesis and activation but requires adequate glutathione. When your liver is clogged from fat, it creates stress, depletes glutathione, and impairs vitamin D activation.

Fatty liver congestion is a common result of sedentary lifestyles, high carbohydrate diets, and obesity. It is also directly impacted by insufficient choline intake (a type of B vitamin) and imbalanced gut bacteria. Fatty liver is the most common liver disorder today.

Glutathione Depletion