Greater folate and vitamin B6 intake linked to lower risk of mortality during 9.8-year period

Zhengzhou University (China), July 6 2022.


A study published in Nutrients revealed a decreased risk of death during a median period of 9.8 years among men and women with a greater intake of vitamin B6 and the B vitamin folate compared to those whose intake was lower.

The investigation included 55,569 participants enrolled in the National Health and Nutrition Examination Survey (NHANES) and eight cycles of the continuous NHANES that occurred between 1999 and 2014. Dietary recall interview responses were analyzed for the intake of folate, vitamin B6 and vitamin B12.

Men whose intake of folate was among the top 25% of individuals in the study had a 23% lower risk of death from any cause, a 41% lower risk of cardiovascular disease mortality and a 32% lower risk of cancer mortality during follow-up than those whose intake was among the lowest 25%. Among women in the top 25%, the risks of all-cause and cardiovascular mortality were 14% and 47% lower.

For men whose intake of vitamin B6 was among the highest 25% of those included in the study, the risk of all-cause mortality was 21% lower, cardiovascular disease mortality was 31% lower and cancer mortality was 27% lower compared to individuals whose intake was lowest. The risk of mortality among women whose vitamin B6 intake was among the top 25% was 12% lower than those whose intake was among the lowest 25% and their risk of dying from cardiovascular disease was 44% lower.