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Personalize Your COVID-19 Prevention An Orthomolecular Protocol

by Michael J Gonzalez, NMD, PhD

OMNS June 4, 2020) Much has been said on how to prevent infection by the Sars-Cov2 coronavirus (COVID-19). Washing hands, using sanitizers, keeping physical distance, wearing a mask are all good primary prevention advice, but it may be said that a virus anywhere is a virus everywhere. The Sars-Cov2 that produces the COVID-19 seems to have certain particularities such as being highly infectious, surviving for long periods of time on different surfaces, and a fairly fast mutation rate, all which enhance the chances of getting infected and it lasting more than usual for a viral infection. Like the flu virus, COVID-19 is transmitted from infected people to others via respiratory fluids.

So what can we do? Most of the individuals that actually get complications when infected by Sars-Cov2 have a compromised immune system, apparently due to two main factors:

  1. Co- morbidities (obesity, diabetes, cancer, heart disease).

  2. Nutrient insufficiencies or deficiencies.

The immune system is one of the most complex systems in our body requiring multiple metabolic steps for its proper functioning. Moreover, its multiple metabolic steps require many enzymes which need numerous cofactors (vitamins and minerals). If these cofactors are not provided in an optimal level, the immune system will not be capable of responding properly to defend us from invading organisms and viruses.

The Sars-Cov2 coronavirus is an RNA virus with spikes on its capsid or protein coat. The virus spike protein utilizes angiotensin-converting enzyme 2 (ACE2) as its cell surface receptor and affects organs such as lung, intestine and heart with high numbers of these receptors.

The most common clinical manifestations of COVID-19 are fever, cough, and dyspnea. Other reported symptoms include sore throat, myalgia, fatigue, headache, and diarrhea. Loss of smell and taste have also been reported as distinctive features of this viral disease. Most of the critical and fatal damage that occurs with this infection is due to the cytokine storm induced by the virus.

The cytokine storm refers to an excessive and uncontrolled release of pro-inflammatory cytokines that significantly upregulate reactive oxidative species that destroy the tissues. In infectious diseases, the cytokine storm usually originates from the infected area, spreading through the bloodstream. Damage has been reported to the alveoli in the lungs where the gas exchange between O2 and CO2 occurs, to the vascular systems that carries O2 through all the body, and to the red blood cells that transport the O2. This explains why respiratory distress and sepsis occurs in a number of COVID-19 patients that increases their need for intensive care and respirators, and risk of death. Scavengers of reactive oxygen species, such as vitamin C and other antioxidants, can play an important role in minimizing the cytokine storm and preventing tissue damage. But in doing so, the level of vitamin C can be rapidly depleted if not replenished.

To prevent tissue damage and lower the risk of death, we must prepare the immune system to function quickly and more effectively! Only by having a prepared and strong immune system will you be able to protect yourself and reduce your infection risk. So here are a few recommendations to optimize your immune system to help you fight more effectively any viral infection. This protocol will not prevent you from becoming infected but will provide your body with necessary cofactors to ameliorate many of the serious complications of the disease.

Orthomolecular COVID-19 Prevention protocol


Follow a diet rich in whole foods high in antioxidants (Citrus fruits, Yogurt, Almonds, Spinach, Garlic and onions, Ginger, Broccoli, Red bell peppers, etc.)

  • Diet low in sugar and low in simple and refined carbohydrates

  • Limit processed meals

  • Eat more vegetables, fruits and nuts.

  • Hydrate well with water! (Your weight in lb. divided by 16 gives you the number of 8oz cups daily intake)


  • Sleep 8 hours

  • Exercise at least 3 times a week

  • Relaxation: Meditate, Listen to music, Read a book

Recommended supplementation (basic): Take immune-optimizing supplements. There are a number of supplements you can take that will improve your immunity to disease.

  1. Multivitamin and mineral, one daily

  2. Vitamin C 1,000 mg, three times daily, reduce if it causes laxative effect.

  3. Vitamin D 2,000 - 5,000 IU daily depending on body weight, 10,000 IU daily for the first 2 weeks

  4. Zinc 30 mg daily

  5. Magnesium 500 mg daily (in malate, citrate, or chloride form)

  6. Selenium 200 mcg daily (also contained in many multivitamin supplements)

  7. Probiotics >30 billion a day

  8. Quercetin 500 mg daily

  9. NAC (N-Acetyl-Cysteine) 500 mg daily