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Reduced Kidney Function Leads To Fluoride Accumulation In Blood

Authors Warn Of Effects For Those With Chronic Kidney Disease

Flouride Alert .org


An analysis of the National Health and Nutrition Examination Survey (NHANES) between 2013 and 2016 has found that teenagers who suffer reduced kidney function accumulate more fluoride in their blood.

“Water fluoridation results in higher plasma fluoride levels in those with lower renal function. How routine water fluoridation may affect the many millions of Americans with Chronic Kidney Disease, who are particularly susceptible to heavy metal and mineral accumulation, needs to be further investigated,” write the authors from Beth Israel Hospital in Boston and the Harvard School of Public Health June 7 in Environmental Health (Danziger, et al, 2022).

Reflecting on the implications of their results, the scientists write, “Our findings suggest that renal function influences the degree to which plasma fluoride levels increase in relation to levels of drinking water fluoridation found widely in the United States. While the observed associations were modest, with a 0.11 micromole per liter difference in plasma fluoride concentrations between the highest and lowest quartile of renal function, the healthy and young nature of the study sample may underestimate levels of fluoride accumulation among the many millions of Americans with chronic kidney disease (CKD). Furthermore, given that ingested fluoride is rapidly distributed throughout the body, circulating plasma levels may underestimate levels of fluoride tissue deposition that, in turn, are relevant to toxicity. Accordingly, our observed trend toward effect modification, with higher plasma fluoride levels observed per 1 mg/L water fluoride exposure in those with lower renal function, might suggest even greater unrecognized hazards for individuals with CKD.

“Given that there are more than 20 million Americans living with CKD, among whom the hazard of fluoridation would be highest in those with severe disease, further research is needed to assure water safety for all,” they conclude.

SOURCE: https://doi.org/10.1016/j.envres.2022.113603 On FAN: https://fluoridealert.org/studytracker/42588/