Richard Z. Cheng, M.D., Ph.D.
Abstract
Vitamin D resistance, a condition where the body inadequately responds to vitamin D, can manifest in both hereditary and acquired forms. This paper examines the complexities of vitamin D resistance, highlighting the multifactorial nature of the condition, which involves genetic predispositions, lifestyle factors, infections, hormonal imbalances, and micronutrient deficiencies. Hereditary forms, though rare, typically involve mutations in the vitamin D receptor (VDR), while acquired resistance is increasingly common and often associated with chronic illnesses and environmental factors.
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